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Publications

The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): A research program striving to improve blood donor and transfusion recipient outcomes
Steven Kleinman MD, Michael P Busch MD, PhD, Edward L Murphy MD, MPH, Hua Shan, Paul Ness, Simone A. Glynn MD, MPH for The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III). Transfusion. 2014; 54 (No 3, Part II): 942-955; doi:10.1111/trf.12468 (PMID: 24188564)Offsite icon

Oral Iron Suppplementation After Blood Donation: A Randomized Clinical Trial
Joseph E. Kiss, MD1; Donald Brambilla, PhD2; Simone A. Glynn, MD3; Alan E. Mast, MD, PhD4; Bryan R. Spencer, MPH5; Mars Stone, PhD6; Steven H. Kleinman, MD7; Ritchard G. Cable, MD8 ; for the National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). JAMA. 2015; 313(6):575-583. doi:10.1001/jama.2015.119. (PMID: 25668261) Offsite icon

Trends in Red Blood Cell Transfusion and 30-Day Mortality among Hospitalized Patients.
N.H. Roubinian, G.J. Escobar, V. Liu, B.E. Swain, M.N. Gardner, P. Kipnis, D.J. Triulzi, J.L. Gottschall, Y. Wu, J.L. Carson, S.H. Kleinman, E.L. Murphy, for the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Transfusion. 2014; 54 (No 10, Part II): 2678-2686. doi: 10.1111/trf.12825. (PMID: 25135770) Offsite icon

Predicting Red Blood Cell Transfusion in Hospitalized Patients: Role of Hemoglobin Level, Comorbidities, and Illness Severity.
Roubinian N. Murphy EL, Swain BE, Gardner MN, Liu V, Escobar GJ. for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). BMC Health Services Research. 2014; doi:10.1186/1472-6963-14-213.  (PMID: 24884605) Offsite icon

Decreased Red Blood Cell Use and Mortality in Hospitalized Patients.
N.H. Roubinian, G.J. Escobar, V. Liu, M.N. Gardner, J.L. Carson, S.H. Kleinman, E.L. Murphy, for the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Research Letter. JAMA Intern Med. 2014; 174(8):1405-1407. doi:10.1001/jamainternmed.2014.2889. (PMID: 24978650) Offsite icon

Downregulation of Cytokines and Chemokines by GB Virus C After Transmission Via Blood Transfusion in HIV-Positive Blood Recipients.
Marion C. Lanteri; Farnaz Vahidnia; Sylvia Tan; Jack T. Stapleton; Philip J. Norris; John Heitman; Xutao Deng; Sheila M. Keating; Don Brambilla; Michael P. Busch; Brian Custer; Journal of Infectious Diseases. 2014; doi: 10.1093/infdis/jiu660. (PMID: 25425697) Offsite icon

Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil.
Ester C. Sabino; Paula Loureiro; Maria Esther Lopes; Ligia Capuani; Christopher McClure; Dhuly Chowdhury; Claudia Di-Lorenzo-Oliveira; Lea C. Oliveria; Jeffrey M. Linnen; Tzong-Hee Lee; Thelma Goncalez; Donald Brambilla; Steve Kleinman; Michael P. Busch; Brian Custer for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Journal of Infectious Diseases. 2015; doi: 10.1093/infdis/jiv326. (PMID: 26908780) Offsite icon

Study of Seroprevalence and Rates of Asymptomatic Viremia of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) among Chinese Blood Donors.
Peibin Zeng, Lili Ma, Zhan Gao, Jingxing Wang, Jing Liu, Xianwei Huang, Qizhi Yang, Ruan Cao, Xiuqiong Wen, Lili Zhu, Hongli Ma, Zhendong Yang, Tzong-Hae Lee, Donald Brambilla, Michelle Yuan, Simone Glynn, Paul Ness, Steve Kleinman, Michael Busch, and Hua Shan, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion. 2015; 55(5): 965-71. (PMID: 25496479) Offsite icon

The impact of Human Immunodeficiency Virus infection on obstetric hemorrhage and blood transfusion in South Africa.
Evan M. Bloch, Robert L. Crookes, Jennifer Hull, Sue Fawcus, Rajesh Gangaram, John Anthony, Charlotte Ingram, Solomuzi Ngcobo, Julie Croxford, Darryl V. Creel, Edward L. Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion. 2015; 55(7):1675-84, doi: 10.1111/trf.13040. (PMID: 25773233) Offsite icon

A multicenter study of plasma use in the United States.
Darrell Triulzi, Jerome Gottschall, Edward Murphy, Yanyun Wu, Paul Ness, Daryl Kor, Nareg Roubinian, Debra Fleischmann, Dhuly Chowdhury, and Donald Brambilla for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion. 2015; 55(6):1313-19; doi: 10.1111/trf.12970. (PMID: 25522888) Offsite icon

Motivators and deterrents to blood donation among Black South Africans: a qualitative analysis of focus group data.
Muthivhi, T., Olmsted, M. G., Park, H., Sha, M., Raju, V., Mokoena, T., Bloch, E., Murphy, E. L., & Reddy, R., Transfusion Medicine. 2015; 25(4): 249-258; doi: 10.1111/tme.12218. (PMID: 26104809) Offsite icon

Blood donor deferral for men who have sex with men: the Blood Donation Rules Opinion Study (Blood DROPS).
Brian Custer, Nicolas Sheon, Bob Siedle-Khan, Lance Pollack, Walter Bialkowski, Bryan Spencer, Pam D'Andrea, Marian Sullivan, Simone Glynn, Alan Williams; Transfusion. 2015; 55(12):2826-34. doi: 10.1111/trf.13247. (PMID: 26202349) Offsite icon

Saving lives, maintaining safety, and science-based policy: qualitative interview findings from the Blood Donation Rules Opinion Study (Blood DROPS).
Shana Hughes, Nicolas Sheon, Bob Siedle-Khan, and Brian Custer for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion. 2015; 55(12):2835-41; doi: 10.1111/trf.13268. (PMID: 26271755) Offsite icon

Duration of Dengue Viremia in Blood Donors and Relationships Between Donor Viremia, Infection Incidence and Clinical Case Reports During a Large Epidemic.
Busch MP, Sabino EC, Brambilla D, Lopes ME, Capuani L, Chowdhury D, McClure C, Linnen JM, Prince H, Simmons G, Lee TH, Kleinman S, Custer B; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). J Infect Dis. 2016 Jul 1;214(1):49-54. doi: 10.1093/infdis/jiw122. Epub 2016 Apr 1. (PMID: 27302934) Offsite icon

Ultra-Deep Sequencing of HIV-1 near Full-Length and Partial Proviral Genomes Reveals High Genetic Diversity among Brazilian Blood Donors.
Pessôa R, Loureiro P, Esther Lopes M, Carneiro-Proietti AB, Sabino EC, Busch MP, Sanabani SS. PLoS One. 2016 Mar 31;11(3):e0152499. doi: 10.1371/journal.pone.0152499.eCollection 2016. (PMID: 27031505) Offsite icon

Enhanced detection of viral diversity using partial and near full-length genomes of human immunodeficiency virus Type 1 provirus deep sequencing data from recently infected donors at four blood centers in Brazil.
Pessôa R, Watanabe JT, Calabria P, Alencar CS, Loureiro P, Lopes ME, Proetti AB, Félix AC, Sabino EC, Busch MP, Sanabani SS; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion. 2015 May;55 (5):980-90. doi: 10.1111/trf.12936. Epub 2014 Nov 21. (PMID: 25413141) Offsite icon

Deep sequencing of HIV-1 near full-length proviral genomes identifies high rates of BF1 recombinants including two novel circulating recombinant forms (CRF) 70_BF1 and a disseminating 71_BF1 among blood donors in Pernambuco, Brazil.
Pessôa R, Watanabe JT, Calabria P, Felix AC, Loureiro P, Sabino EC, Busch MP, Sanabani SS; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III. PLoS One. 2014 Nov 17;9(11):e112674. doi: 10.1371/journal.pone.0112674. eCollection 2014. (PMID: 25401747) Offsite icon

 

Abstract Presentations - American Association of Blood Banks (AABB)

Annual Meeting 2016

Hepatitis B Virus Prevalence in Chinese Blood Donors: HBsAg-reactive rates from Pre-donation Rapid Test and Post-donation Screening Test
M He, J E Liu, Y Liu, W Mao, T He, M Huang, R Cao, D Liao, J Wang, H Shan.

ABO and RhD Blood Groups and Susceptibility to HIV Infection among South African Blood Donors
G A Beck, M Vermeulen, D Chowdhury, C F Ingram, R Reddy, B Custer, E L Murphy.

Peripartum Blood Transfusion in South Africa: An Association between HIV Infection and Risk of Transfusion
E Bloch, C F Ingram, J Hull, S Fawcus, J Anthony, R Green-Thompson, R Crookes, S M Ngcobo, D Creel, L C Courtney, E L Murphy.

Inflammatory and Cardiopulmonary Biomarker Characterization of Pulmonary Transfusion Reactions
N Roubinian, M Looney, P Toy, S Keating, P J Norris, C Lowell, D Kor, O Gajic, R Hubmayr, M Gropper, G Wilson, M Matthay, E Murphy.

Development and Evaluation of a Transfusion Medicine Genome-wide SNP Array
G P Page, Y Guo, M Seielstad, B Keating, C M Westhoff, C Hoppe, A Bordbar, B Custer, Y Lu, M Busch for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Oral Presentations

Incidence of Transfusion Reactions: A Multicenter Study Utilizing Systematic Active Surveillance and Expert Adjudication
J E Hendrickson, N Roubinian, D Chowdhury, D Brambilla, E Murphy, Y Wu, P M Ness, E Gehrie, E Snyder, R G Hauser, J Gottschall, S Kleinman, R Kakaiya, R Strauss.

Effect of Age, Sex, or Frequency of Blood Donations on Donors’ Ferritin Levels and RBC Storage Stability
T Kanias, M C Lanteri, S Keating, G P Page, D Brambilla, S M Endres, A E Mast, R G Cable, D J Triulzi, J E Kiss, M T Gladwin, S Kleinman, M Busch.

 

Abstract Presentations - American Association of Blood Banks (AABB)

Annual Meeting 2015

Genetic, Ethnic and Gender Determinants of Red Blood Cell Storage and Stress Hemolysis
T Kanias, M C Lanteri, SM Keating, D Brambilla, S M Endres, S H Kleinman, M T Gladwin, M P Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Incidence and Clinical Characteristics of Transfusion-Associated Circulatory Overload (TACO) by Using an Electronic Health Record Surveillance Algorithm
N Roubinian, J E Hendrickson, J Gottschall, D Triulzi, D J Kor, D Chowdhury, S H Kleinman, E L Murphy, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Establishing a Multicenter Transfusion Recipient Database: Feasibility and Potential Use
M S Karafin, R Bruhn, N Roubinian, M Westlake, J Gottschall, D J Kor, D Fleischmann, R Hauser, E L Murphy, D Triulzi, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Hemoglobin Triggers for Red Blood Cell Transfusion in the NHLBI Recipient Epidemiology and Donor Evaluation Study III (REDS-III) Program Transfusion Recipient Database
R Bruhn, M S Karafin, N Roubinian, M Westlake, J Gottschall, D J Kor, D Fleischmann, E L Murphy, D Triulzi, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Prevalence of HIV, Hepatitis B and C viruses in South African Blood Donors, 2012-2014
M Vermeulen, R Swanevelder, D Chowdhury, C Ingram, V Reddy, T Muthivhi, E Bloch, B Custer, E L Murphy, for the International Component of NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

The Staging, Genotypic Distribution and Drug Resistance Mutation Profiles of HIV among Infected Blood Donors from Five Chinese Blood Centers, 2012-2014
P Zeng, J Wang, J Liu, W Mao, X Bi, J Li, L Zhu, R Cao, D Liao, H Shan, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Frequency of Anti-HIV Confirmed by Western Blot and Donor Characteristics at Five Chinese Blood Centers
Z Gao, M He, J Wang, J Liu, T He, J Xu, Y Lv, X Wen, H Zhang, H Shan, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Variability in HIV Prevalence and Incidence among First-time Blood Donors in Brazil Before and After Introduction of NAT
E C Sabino, B Custer, S M Keating, L Preiss, A Mendrone, L Amorim, A Carneiro Proietti, P Loureiro, M K Oikawa, D Brambilla, M P Busch, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Intra-donor Reproducibility and Changes in Hemolytic Parameters during RBC storage
M C Lanteri, T Kanias, S M Keating, D Brambilla, B R Spencer, W Bialkowski, P D’Andrea, S H Kleinman, M T Gladwin, M P Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

 

Abstract Presentations - American Society of Hematology (ASH)

Annual Meeting 2014

Effects of Storage Iron on Erythropoietin and Hepcidin Responses to Acute Hemorrhage
A E Mast, J Kiss, R G Cable, S Glynn, and Donald Brambilla, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Downregulation of cytokines and chemokines by GB virus C after transfusion-transmission in HIV + blood recipient
M C. Lanteri, F Vahidnia, S Tan, J T Stapleton, P J Norris, J Heitman, X Deng, S Keating, D Brambilla, M P Busch, B Custer, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

 

Abstract Presentations – American Association of Blood Banks (AABB)

Annual Meeting 2014

Symptoms and Outcomes of Dengue Among Transfusion Recipients in Brazil who were RNA+ of Who Received an RNA+ unit Compared to RNA- Recipients
E C Sabino, C D Oliveira, P Loureiro, M Lopes, L D Capuani, C McClure, D Chowdhury, S Kleinman, M Busch, B Custer, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Noncompliance with the Men Who Have Sex with Men (MSM) Deferral among Male U.S. Blood Donors
B Custer, N Sheon, B Siedle-Khan, L M Pollack, B R Spencer, W Bialkowski, P A D’Andrea, M Sullivan, S Glynn, A Williams, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Quantification of Iron Stores, Body Iron, and Iron Absorption in Blood Donors: Effect on Iron Supplementation
R G Cable, D Brambilla, S Glynn, A E Mast, J E Kiss, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

High Proportion of Anti-HCV EIA False-positive Results among Chinese Blood Donors: A Multi-center Study
M He, Z Gao, D Chowdhury, J Wang, W Mao, Y Lv, X Bi, R Cao, J Xu, H Shan, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Screening and Confirmatory Test-Positive Rates of HBsAg among Blood Donors from Five Chinese Blood Centers
Y Liu, M He, J Liu, H Liao, L Zhu, X Li, X Wen, J Li, D Chowdhury, H Shan, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Seroprevalence and Rates of Asymptomatic Viremia of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Chinese Blood Donors
P Zeng, J Wang, X Huang, R Cao, L Zhu, T Lee, J Liu, M Yuan, P M Ness, H Shuan, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

 

Abstract Presentations – American Society of Hematology (ASH)

Annual Meeting 2013

The TMPRSS6 Ala736Val Polymorphism is Associated with Decreased Hemoglobin and Iron Status in Females Undergoing Repeated Phlebotomy
AE Mast, J Langer, W Bialkowski, S Glynn, TH Lee, JE Kiss, RG Cable, M Busch, D Brambilla, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

 

Abstract Presentations – International Society of Blood Transfusion (ISBT)

Annual Meeting 2013

Predicting Red Blood Cell Transfusion in Hospitalized Patients using Electronic Medical Records
NH Roubinian, EL Murphy, BE Swain, MN Gardner, D Triulzi, JL Gottschall, B Custer, R Bruhn, J Carson, SH Kleinman, V Liu, GJ Escobar, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Motivators and Deterrents to Blood Donation among Black South Africans: A Qualitative Analysis of Focus Group Data
R Reddy, M Olmsted, T Muthivhi, H Park, M Sha, T Mokoena, V Raju, K Mathavha, B Russell, E Bloch, R Crookes, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

The Impact of HIV Infection in Obstetric Hemorrhage and Blood Transfusion in South Africa
EM Bloch, R Crookes, J Hull, R Gangaram, S Fawcus, J Anthony, C Ingram, S Ngcobo, JA Croxford, D Creel, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Dengue RNA among blood donors and recipients during large epidemics of DEN4 in Rio de Janeiro and Recife, Brazil
EC Sabino, P Loureiro, ME Lopes, L Capuani, C Oliveira, L Oliveira, L Ferreira, H Domingues, TH Lee, T Gonçalez, B Custer, M Busch, D Brambilla, D Chowdhury, C McClure, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

An analysis of blood donor informed consent for future use of samples collected during a transfusion-transmitted infectious disease study in two blood banks in Brazil
L Capuani, P Loureiro, I Gerreiro, ME Lopes, C Di Lorenzo, H Domingues, T Gonçalez, C McClure, B Custer, EC Sabino, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Prevalence of Symptomatic Dengue Virus Infection in Transfused Patients
B Custer, EC Sabino, C McClure, D Chowdhury, P Loureiro, M Lopes, C Lorenzo, L Capuani, T Gonçalez, J Linnen and M Busch, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

 

Abstract Presentations – American Association of Blood Banks (AABB)

Annual Meeting 2013

Hemoglobin Recovery after Blood Donation and the Effects of Iron Supplementation: The Hemoglobin and Iron Recovery Study (HEIRS)
JE Kiss, RG Cable, D Brambilla, S Glynn, AE Mast, BR Spencer, M Stone, LH Tobler, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

A Descriptive Analysis of Plasma use in the REDS-III Hospital Network
D Triulzi, J Gottschall, EL Murphy, E Fiebig, Y Wu, PM Ness, D Kor, D Chowdhury, D Fleischman, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Genome-Wide Association Study of HLA Allo-Antibody Formation and Persistence
M Seielstad, G Page, N Gaddis, X Deng, T Lee, MC Lanteri, Y Wu, R Kakaiya, MP Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Predictors of Venous Hemoglobin in the Week Following Whole Blood Donation
RG Cable, D Brambilla, S Glynn, JE Kiss, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Racial Differences in Syncope Rates among South African Blood Donors
K Van den Berg, E Bloch, N Moleli, C Ingram, R Swanevelder, T Muthivhi, J Langer, B Custer, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Peripartum Blood Transfusion in South Africa: Contributions of Prenatal Anemia, Obstetric Hemorrhage, and Inter-Hospital Variation
JC Hull, R Gangaram, S Fawcus, J Anthony, E Bloch, R Crookes, C Ingram, SM Ngcobo, JA Croxford, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

Transfusion Epidemiology of Hospitalized Patients in the United States: Data from an Integrated Health Care Delivery System
N Roubinian, GJ Escobar, BE Swain, MN Gardner, V Liu, DJ Triulzi, J Gottschall, Y Wu, S Kleinman, EL Murphy, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

 

Abstract Presentations – American Association of Blood Banks (AABB)

Annual Meeting 2012

Sources of Variation in Plasma Ferretin Levels Relevant to Use of Ferritin for Monitoring Iron Stores in Blood Donors
M Stone, K Murcia, P Loanzon, RG Cable, JE Kiss, D Brambilla, L Tobler, M Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).

 


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