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REDS-III Transfusion Medicine Research Program in Brazil

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Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

Blood Systems Research Institute (BSRI), the University of California San Francisco (UCSF), Fundação Pró-Sangue (FPS) - the blood center in Sao Paulo and the University of Sao Paulo – have a long (20 years) and successful record of collaborative research focusing on the epidemiology of transfusion-transmitted infections, with particular reference to emerging infections and HIV/AIDS research. These studies laid the foundation for the REDS-II and REDS-III projects. The REDS Brazil International Programs (REDS-II and REDS-III) have dramatically improved the quality and impact of the Transfusion Medicine research performed in Brazil, as detailed below.

The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Brazil International Program addresses scientific questions on the safety and adequacy of the blood supply in Brazil. The goal of this program is to improve the safety and effectiveness of blood banking and transfusion medicine practices in Brazil by performing laboratory, survey, and epidemiological research.

It is a partnership between Blood Systems Research Institute (BSRI, San Francisco, CA, USA) and Fundação Pró-Sangue (FPS, Sao Paulo, Brazil) along with faculty at the University of São Paulo (USP, Sao Paulo, Brazil). The FPS/USP investigators serve as the in-country operations center which provides day-to-day project oversight. Under the direction of BSRI and FPS/USP, the Computer Science department at the University of Sao Paulo operates the in-country Central Coordinating Center (CCC).

The REDS-III Brazil Program is built upon the previously successful collaborations between BSRI and these blood centers under the REDS-II Program (2007-2011, described below) and other research and training projects sponsored by Fogarty Foundation, BSRI, the Brazilian Ministry of Health, the São Paulo Research Foundation (FAPESP) and the National Council of Scientific and Technological Development (CNPq).

 Participating Blood Centers:

Fundação Pró-Sangue and three other representative public blood centers in Brazil, also referred to as hemocenters, participate in the REDS-III Brazil International Program. For REDS-III, FPS/USP provides assistance to BSRI in all aspects of project coordination. The FPS/USP Confirmatory and Molecular Laboratory conducts HIV supplemental (confirmatory) testing and molecular testing for REDS-III Brazil sites. The role of the hemocenters is to contribute donors and donation data to the longitudinal database, as well as participate in specific REDS-III protocols.

The four participating blood centers are located in the cities of:

The four blood centers are diverse in terms of geography, population density, ethnicity, blood donor and donation characteristics (i.e. donation frequency, type of donation), socioeconomic development, and some centers collect in cities with relatively high HIV/AIDS prevalence. Research protocols with prominent HIV related research components are the cornerstone for this and the other REDS-III International programs.

 Brazil study sites: São Paulo - Fundação Pró-Sangue, Belo Horizonte - Fundação Pró-Sangue Fundação Hemominas, Recife - Fundação Hemope, and Rio de Janeiro - Fundação Hemorio

The current projects for REDS-III Brazil International Program include:

Longitudinal Donor and Donation Database:
Data on blood donations and donors at all participating Brazilian blood centers are collected. The data collected is comparable to earlier REDS-II program and will create a donor and donation database that spans the years 2007 to 2017. Donor and donation is submitted to the in-country Central Coordinating Center whose staff review, collate, revise and transfer the data for storage and analysis at RTI International, the REDS-III Data Coordinating Center (DCC). Using the REDS-III donor and donation database, investigators address many questions relating to blood safety and availability in Brazil, such as donor demographic characteristics associated with desirable donation behaviors, deferral patterns and reasons, donor adverse reactions, and infectious marker trends in blood donors.

Prevalence, Incidence, Epidemiology and Molecular Variants of HIV in Blood Donors in Brazil (More info)

Establishing a Brazilian Sickle Cell Disease Cohort and Identifying Molecular Determinants of Response to Transfusions, Genetic Determinants of Alloimmunization, and Risk Factors Associated with HIV Infection (More info)

Dengue Virus Incidence and Prevalence in Brazilian Donors and Recipients, Rates and Correlates of Transfusion-Transmission, and Clinical Outcomes of Infection in Recipients (More info)

Improving the Safety of Blood Donation in Brazil through an Assessment of the Effectiveness of Notification and Counseling and Linkage of HIV-Positive Donors to Health Care   (More info)

Human subjects’ research. All study protocols are submitted for approval by the local Research Ethics Committees as well as the Brazilian National Health Council (CONEP), RTI and UCSF/BSRI before implementation. All facets of the studies comply with NIH and International Research Ethics Guidelines. Human subjects participating in all REDS-III studies in Brazil always provide informed consent.



Brazilian Investigators by Organization

Fundação Pró-Sangue Hemocentro de São Paulo/Universidade de São Paulo Faculdade de MedicinaOffsite icon
Ester Sabino, MD, PhD
Cesar de Almeida Neto, MD, PhD
Alfredo Mendrone Junior, PhD
Jose Eduardo Levi, PhD
João Eduardo Ferreira, PhD
Ligia Capuani

Fundação Hemominas (Centro de Hematologia e Hemoterapia de Minas Gerais)Offsite icon
Anna Bárbara Proietti, MD, PhD
Cláudia Di Lorenzo Oliveira, MD, PhD
Fernando Basques, MD
Elizabeth Moreno Castro, PhD, MS

Fundação HemopeOffsite icon
Adérson Araujo, MD, PhD
Paula Loureiro, MD, MSc, PhD
Silvana Leão, MD
Divaldo de Almeida Sampaio, MD, PhD

Fundação Hemorio (Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti)Offsite icon
Clarisse Lobo, MD
Maria Esther Lopes, MD
Cláudia de Alvarenga Máximo, MD, MS


US Investigators by Organization

Blood Systems Research InstituteOffsite icon
Brian Custer, PhD, MPH
Michael Busch, MD, PhD 
Shannon Kelly, MD
Thelma T Gonçalez, MD, PhD

RTI InternationalOffsite icon
Christopher McClure, MPH

 

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